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Check-in
17Dec2025Select date
Check-out
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Rooms and Guests2 Guests, 1 Room
Key details

Hotel overview and key features

700 West Main Street, Louisville, Kentucky, United States, 40202
-
Steps from Waterfront Park
Great
8.6
9.3
/10
4.7
4.6
/5

21C Museum Hotel Louisville, a 5-star hotel with a 9.1/10 Booking.com rating, is located in Downtown Louisville near the Kentucky Museum of Art & Craft, Frazier International History Museum, and Muhammad Ali Center, all within a half mile. The hotel near airport offers easy access via the free electric ZeroBus, located two roads down, which circulates along Main and Market streets, passing Whiskey Row and Slugger Field.

Luxury Sleep & Space

Guest rooms at 21c Louisville feature premium Bryte Restorative Sleep Beds with customizable firmness and temperature settings. The largest room includes an open floor plan with a king-sized bed, living and dining areas, and a connecting king bedroom. Multi-purpose furniture and antique pieces like a writing desk and rocking chair complement the contemporary design.

Bourbon & Dining

Proof on Main, the hotel's on-site restaurant, serves southern and Appalachian-inspired cuisine, including bourbon-focused dishes from the 21c Selects Private Barrel Program. The Fork & Bottle dinner series features guest distillers and regional spirits, while the Hog & Barrel dinner highlights Pappy Van Winkle. Catering menus can be tailored for private events.

Art & Events

21c Louisville houses over 9000 square feet of exhibition space, showcasing contemporary art like Fragile Figures: Beings and Time. Guests can attend events such as the Fork & Bottle series or immersive performances inspired by the museum's installations. The hotel is steps from Revelry Boutique Gallery, featuring over 150 regional artists.

Wellness & Meetings

The hotel offers reflexology and sports massages, targeting reflex points and athletic recovery. Dedicated event staff assist with eco-conscious meetings, while four private galleries accommodate groups of 10 to 60. 21c Museum Hotel Louisville also provides access to River City Tintype for unique photography experiences.

“This hotel distinguishes itself with seamlessly integrated art installations and a lively bourbon bar; its location near Whiskey Row is excellent for visitors. The curated guest rooms amplify the immersive art experience, and the commitment to eco-friendly practices is admirable. A top recommendation for those seeking a unique blend of culture and comfort in Louisville.”
Hotel logo
Amelia BrooksLead Hotel Editor at Hotelairport
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Choose your ideal room style

Choose from family rooms, suites, flexible cancellation & more
Room Balcony
2 persons
29 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
31 m² 
1 King-size bed
Shower
Coffee machine
Corner Suite
2 persons
61 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
46 m² 
1 King-size bed
Shower
Coffee machine
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Prices and Availability

Check availability and prices for your travel dates right now!

Facilities

Stay relaxed and refreshed just minutes from the airport

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
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Dining Onsite

Dining at 21C Museum Hotel Louisville invites travelers to savor modern American cuisine infused with local spirits and traditions. The hotel's signature restaurant, Proof on Main, offers a vibrant atmosphere paired with unique culinary experiences, including engaging events that celebrate regional flavors and craftsmanship.
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo

Proof on Main

American
Ambiance
Modern setting adorned with contemporary art, providing a creative backdrop for dining experiences.
Key Offerings
Signature dishes feature local ingredients and innovative pairings, complemented by the Fork & Bottle dinner series showcasing guest distillers. Annual events like the Hog & Barrel dinner featuring Pappy Van Winkle add an exclusive touch to the dining experience.
Reservation
Recommended.
Hours vary.

Location info

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
180 m
Museum
Muhammad Ali Center
280 m
Museum
Kentucky Science Center
140 m
Museum
The Frazier History Museum
260 m
Museum
Kentucky Museum of Art and Craft
70 m
528 W Main St
Evan Williams Bourbon Experience
200 m
Gallery
Flame Run Glass Studio and Gallery
300 m
500 W Main St
The Belvedere
250 m
Night club
Jimmy Can't Dance
90 m
801 W Main St
Michter's Fort Nelson Distillery
150 m
Library
Sons of the American Revolution Genealogical Research Library
190 m
120 N 10th St
Kentucky Peerless Distilling Co
480 m
401 W River Rd
Belle of Louisville Riverboats
580 m
Restaurants
Proof On Main
10 m
702 West Main Street
Mussel & Burger Bar Downtown
60 m
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
110 m
614 W Main St
Atlantic No. 5
160 m
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
180 m
445 E Market St
Vincenzo's Italian Restaurant
430 m
150 S 5th St
Jockey Silks Bourbon Bar
480 m
140 N 4th St 2nd Floor - West Tower
Dish on Market
470 m
434 W Market St
Quiznos
540 m
223 S 5th St
Swizzle Dinner & Drinks
530 m
140 N Fourth St 25th Floor
Cafe Magnolia
590 m
140 N 4th St Galt House Hotel
Explore Louisville
Local Highlights
Top Attractions
Activities
Dining
Entertainment
Louisville Slugger Museum & Bat Factory
Louisville Slugger Museum & Bat Factory
3 minutes walking
Home of the iconic baseball bat, featuring interactive exhibits and a factory tour, showcasing the history of baseball.
Muhammad Ali Center
Muhammad Ali Center
4 minutes walking
A museum dedicated to the life of Muhammad Ali, focusing on his boxing career and community activism with unique exhibits.
Kentucky Science Center
Kentucky Science Center
2 minutes walking
An interactive science museum ideal for families, featuring hands-on exhibits and a 4D theater experience.
The Frazier History Museum
The Frazier History Museum
4 minutes walking
Showcases a diverse range of Kentucky history exhibits; includes a popular toy museum and offers guided tours.
Lawn Games at Waterfront Park
17 minutes walking
A green space perfect for picnics and outdoor games. Ideal for relaxation and family gatherings in a scenic environment.
Biking along the Big Four Bridge
25 minutes walking
A popular walking and biking bridge offering views of the Ohio River; rental bikes available nearby for a fun ride.
Distillery Tours
11 minutes walking
Local distilleries like Angel's Envy and Old Forester provide guided tours and tastings, showcasing the bourbon-making process.
Proof On Main
Proof On Main
1 minute walking
Eclectic cuisine with a focus on local ingredients. Notable for its art-filled ambiance and diverse menu options.
Mussel & Burger Bar Downtown
Mussel & Burger Bar Downtown
1 minute walking
Casual eatery specializing in gourmet burgers and mussels; a vibrant atmosphere perfect for a laid-back meal.
Bristol Bar & Grille
Bristol Bar & Grille
2 minutes walking
Known for Southern comfort food with modern twists. Offers a cozy setting with popular brunch options and local beers.
Fourth Street Live!
10 minutes walking
A vibrant venue featuring live music, lively bars, and dining, perfect for an energetic nightlife experience.
KFC Yum Center
KFC Yum Center
9 minutes walking
Multi-purpose venue for concerts and sports events, hosting big names and local talent; check schedule for family events.
Getting around
City Centre
Louisville23 min  ·  1.9 km
Airports
Louisville International Airport (SDF)18 min  ·  11.9 km
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
is available in for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel
FAQs
About 21C Museum Hotel Louisville
What is the check-in and check-out policy at 21C Museum Hotel Louisville?
Check-in is at 16:00 and check-out is by 11:00.
Which notable attractions are within walking distance from 21C Museum Hotel Louisville?
Nearby attractions include the Muhammad Ali Center (0.5 km), Louisville Slugger Museum & Factory (0.5 km), and the Kentucky Museum of Art & Craft (1 km).
What types of amenities are available in the rooms at 21C Museum Hotel Louisville?
Rooms include free Wi-Fi, air conditioning, flat-screen cable TVs, minibars, and premium sleep beds.
Is there dining available on-site at 21C Museum Hotel Louisville?
The hotel features the on-site restaurant Proof on Main, which offers unique southern cuisine.
What fitness facilities are available at 21C Museum Hotel Louisville?
The hotel has a 24-hour fitness center, a sauna, and offers yoga classes.
Is parking available at 21C Museum Hotel Louisville?
Valet parking is available for guests at the hotel.
What business services does 21C Museum Hotel Louisville offer?
The hotel provides a business center and 17 meeting rooms for business events.
What nearby restaurants can guests find close to 21C Museum Hotel Louisville?
Nearby dining options include Atlantic No. 5, Main Eatery, and Morton's The Steakhouse, all within 0.5 km.
How far is 21C Museum Hotel Louisville from Louisville International Airport?
The hotel is located approximately 10 km from Louisville International Airport.
What unique features does 21C Museum Hotel Louisville have?
The property hosts contemporary art installations throughout the hotel, offering an immersive art experience.

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